Jorge Ghiso Selected Research

Dementia (Dementias)

1/2022	Identification of Clusterin as a Major ABri- and ADan-Binding Protein Using Affinity Chromatography.
10/2021	Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.
1/2018	The presubiculum is preserved from neurodegenerative changes in Alzheimer's disease.
12/2014	Mitochondrial dysfunction induced by a post-translationally modified amyloid linked to a familial mutation in an alternative model of neurodegeneration.
6/2013	BRI2 interacts with BACE1 and regulates its cellular levels by promoting its degradation and reducing its mRNA levels.
10/2011	Glycosylation of BRI2 on asparagine 170 is involved in its trafficking to the cell surface but not in its processing by furin or ADAM10.
7/2010	PYROGLUTAMATE FORMATION AT THE N-TERMINI OF ABRI MOLECULES IN FAMILIAL BRITISH DEMENTIA IS NOT RESTRICTED TO THE CENTRAL NERVOUS SYSTEM.
4/2010	Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease.
4/2010	Iowa variant of familial Alzheimer's disease: accumulation of posttranslationally modified AbetaD23N in parenchymal and cerebrovascular amyloid deposits.
2/2010	Cerebral amyloidosis: amyloid subunits, mutants and phenotypes.

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Jorge Ghiso Research Topics

Disease

41	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 06/2002
27	Dementia (Dementias) 01/2022 - 02/2001
21	Amyloidosis 01/2016 - 02/2001
14	Amyloid Plaque 01/2022 - 07/2002
14	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 01/2016 - 02/2001
9	familial Danish Dementia 01/2018 - 03/2002
7	Stroke (Strokes) 02/2016 - 02/2001
4	Proteostasis Deficiencies 10/2021 - 07/2005
4	Familial Amyloidosis (Hereditary Amyloidosis) 04/2010 - 09/2003
3	Mitochondrial Diseases (Mitochondrial Disease) 10/2021 - 12/2014
3	Cerebral Hemorrhage 01/2012 - 09/2005
3	Familial Cerebral Amyloid Angiopathy 09/2003 - 02/2001
2	Amyloid angiopathy 01/2022 - 06/2002
2	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2021 - 04/2010
2	Down Syndrome (Down's Syndrome) 10/2021 - 08/2004
2	Cognitive Dysfunction 12/2014 - 01/2012
2	Inflammation (Inflammations) 04/2014 - 12/2002
2	Exfoliation Syndrome 04/2014 - 04/2007
2	Ischemic Stroke 08/2010 - 09/2004
2	Prion Diseases (Transmissible Spongiform Encephalopathies) 07/2009 - 07/2002
1	Huntington Disease (Huntington's Disease) 02/2016
1	Glaucoma 04/2014
1	Edema (Dropsy) 07/2010
1	Neuroinflammatory Diseases 04/2010
1	Memory Disorders (Memory Loss) 06/2008
1	Pathologic Processes 01/2005
1	Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy) 09/2004
1	Nervous System Diseases (Neurological Disorders) 09/2004
1	Atherosclerosis 09/2004

Drug/Important Bio-Agent (IBA)

42	Amyloid (Amyloid Fibrils)IBA 01/2022 - 02/2001
22	Proteins (Proteins, Gene)FDA Link 01/2022 - 03/2002
18	Amyloid beta-PeptidesIBA 02/2016 - 03/2002
11	Peptides (Polypeptides)IBA 01/2022 - 06/2002
4	ClusterinIBA 01/2022 - 01/2005
4	GelsolinIBA 07/2009 - 02/2001
3	ApolipoproteinsIBA 10/2021 - 07/2002
3	Biological ProductsIBA 11/2020 - 09/2006
3	Complement System Proteins (Complement)IBA 04/2014 - 12/2002
3	Metalloproteases (Metalloproteinases)IBA 08/2010 - 01/2006
3	Cystatin CIBA 07/2009 - 07/2002
3	Insulysin (Insulin-Degrading Enzyme)IBA 07/2005 - 06/2003
2	thioflavin TIBA 01/2022 - 09/2009
2	EpitopesIBA 01/2022 - 10/2005
2	Ion Channels (Ion Channel)IBA 10/2020 - 07/2005
2	Apolipoproteins E (ApoE)IBA 01/2010 - 07/2002
2	Prion ProteinsIBA 07/2009 - 09/2003
2	Prealbumin (Transthyretin)IBA 07/2002 - 02/2001
1	Carrier Proteins (Binding Protein)IBA 01/2022
1	Pharmaceutical PreparationsIBA 10/2021
1	Adenosine Triphosphate (ATP)IBA 01/2020
1	Glucose (Dextrose)FDA LinkGeneric 01/2020
1	Flavin-Adenine Dinucleotide (FAD)IBA 01/2018
1	Methazolamide FDA LinkGeneric 02/2016
1	CaspasesIBA 02/2016
1	Carbonic Anhydrase InhibitorsIBA 02/2016
1	Complement Inactivating AgentsIBA 04/2014
1	Protein AggregatesIBA 04/2014
1	Complement Membrane Attack Complex (Membrane Attack Complex)IBA 04/2014
1	VitronectinIBA 04/2014
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 06/2013
1	calpastatinIBA 06/2012
1	Matrix Metalloproteinases (MMPs)IBA 08/2010
1	Oxygen (Dioxygen)IBA 07/2010
1	Free RadicalsIBA 07/2010
1	NitrogenIBA 07/2010
1	Blood Proteins (Serum Proteins)IBA 07/2010
1	Pyrrolidonecarboxylic Acid (Pyroglutamic Acid)IBA 07/2010
1	glutaminyl-peptide cyclotransferaseIBA 07/2010
1	Congo RedIBA 09/2009
1	Nonsense Codon (Nonsense Mutation)IBA 07/2009
1	Serum Amyloid P-ComponentIBA 06/2007
1	formic acid (formate)IBA 04/2007
1	SilverIBA 04/2007
1	Cyanogen BromideIBA 04/2007
1	PrionsIBA 09/2006
1	Neprilysin (Neutral Endopeptidase)IBA 01/2006
1	Endothelins (Endothelin)IBA 01/2006
1	ZincIBA 01/2006
1	EnkephalinsIBA 01/2006
1	Monoclonal AntibodiesIBA 10/2005
1	AntibodiesIBA 10/2005
1	Amyloid beta-Protein Precursor (Amyloid Protein Precursor)IBA 08/2005
1	ImmunosorbentsIBA 12/2004
1	EnzymesIBA 12/2004
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 09/2004
1	CholesterolIBA 09/2004
1	24-hydroxycholesterolIBA 09/2004
1	Lipoproteins (Lipoprotein)IBA 08/2004
1	Amyloidogenic ProteinsIBA 09/2003
1	MelatoninIBA 06/2003
1	Amino Acids FDA Link 06/2003
1	ElementsIBA 09/2002
1	Protein Isoforms (Isoforms)IBA 07/2002

Therapy/Procedure

1	Therapeutics 02/2016
1	Lenses 04/2014